Dynamic clamp analysis of synaptic integration in sympathetic ganglia

Estimating use-dependent synaptic gain in autonomic ganglia by computational simulation and dynamic-clamp analysis.

Biological gain mechanisms regulate the sensitivity and dynamics of signaling pathways at the systemic, cellular, and molecular levels. In the sympathetic nervous system, gain in sensory-motor feedback loops is essential for homeostatic regulation of blood pressure and body temperature. This study shows how synaptic convergence and plasticity can interact to generate synaptic gain in autonomic ...

Modulation of Synaptic Amplification in Sympathetic Ganglia

Slow synaptic transmission in frog sympathetic ganglia.

Bullfrog ganglia contain two classes of neurone, B and C cells, which receive different inputs and exhibit different slow synaptic potentials. B cells, to which most effort has been directed, possess slow and late slow EPSPs. The sEPSP reflects a muscarinic action of acetylcholine released from boutons on B cells, whereas the late sEPSP is caused by a peptide (similar to teleost LHRH) released ...

Synaptic Transmission at Single Boutons in Sympathetic Ganglia.

Synaptic transmission has traditionally been studied at the level of the entire nerve terminal rather than at one of its constituent boutons. Autonomic ganglia provide preparations for recording from individual boutons, as well as for determining the calcium transients necessary for transmitter release at these boutons. The results suggest a new paradigm for synaptic transmission.

dynamic-clamp study of the role of Ih and GABAergic synaptic integration

Title: 1 The mechanism of ethanol action on midbrain dopaminergic neuron firing: a 2 dynamic-clamp study of the role of Ih and GABAergic synaptic integration 3 4 Authors: Takashi Tateno and Hugh P. C. Robinson 5 Affiliation: 6 1) PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho Kawaguchi, Saitama, Japan. 7 2) Department of Physiology, Development and Neuroscience, Downing Street, Cambr...